II International Symposium on Alpha-Synuclein
Alpha-synuclein is a ubiquitous protein in the healthy brain that is found in the presynaptic terminals of neurons. Although its function is not well known, it is believed that it favors the formation of synaptic vesicles that contain neurotransmitters. In particular, it seems that alpha-synuclein has a special role in the regulation of the release of dopamine. Due to different pathological mechanisms, alpha-synuclein can be added forming insoluble intra and extraneuronal fibrillar structures that give rise to the Lewy bodies, characteristic of the set of diseases called synucleinopathies. The most well-known representative of synucleinopathies is Parkinson's disease, which is neither more nor less the second most frequent neurodegenerative disease in the world after Alzheimer's disease. However, the spectrum of synucleinopathies is broader than Parkinson's disease, and it also includes other less frequent diseases such as Lewy body dementia, multiple systemic atrophy, REM sleep behavior disorder and pure autonomic failure. This set of diseases, the synucleinopathies, share many neurobiological and phenotypic similarities, which favors that they often overlap each other.
This symposium, which is the second edition of the meeting with the same name organized by our group at the Biocruces HRI and the Cruces University Hospital in 2016, was born as a result of a double initiative with which, on the one hand, we intend to promote dissemination and training in advances and regional and international research projects related to the pathophysiology, diagnosis and treatment of synucleinopathies, and on the other hand we want to encourage interaction and collaboration among the groups dedicated to the study of synucleinopathies, and also to stimulate students and the personnel in training in the field of biomedicine to become involved in research on synucleinopathies.
- Health staff (doctors, nurses, psychologists, etc.) interested in neurosciences, especially in the field of neurology, neuropsychology, neurophysiology, neuroradiology, neurorehabilitation and neurosurgery.
- Pre-doc and post-doc researchers and undergraduate or master students in the field of biomedicine with an interest in neurosciences (Biology, Biochemistry, Biomedical Engineering, Biophysics, etc.).
Our Group of Neurodegenerative Diseases of BioCruces HRI has a trajectory of more than 10 years dedicated to the study of the phenotype of the genetic forms of Parkinson's disease. Specifically, in 2004 our group first described the E46K mutation of the alpha-synuclein gene (E46K-SNCA) in a family in the Basque Country. This mutation, a genetic anomaly rare and unique in the world, produces a Lewy body disease comparable in many pathological and clinical aspects to the more aggressive idiopathic forms of Parkinson's disease and Lewy body dementia. Therefore, the E46K-SNCA mutation is considered today one of the best in vivo genetic models of synucleinopathies. Since 2004, our group carries out an exhaustive clinical follow-up of the E46K-SNCA carriers, with neurological, neuropsychological, autonomic nervous system, brain neuroimaging and retinal evaluations, among others, which has been continuously supported by institutions such as the Michael J Fox Foundation, the Carlos III Institute and the Basque Government. At present, through collaborations with centers such as the Harvard Stem Cell Institute, the University of Luxembourg or the Achucarro Basque Center for Neuroscience, we are expanding the study of the E46K-SNCA carriers to establish correlations between our clinical findings and the cellular and molecular bases of the mutation and to identify mechanisms and possible therapeutic solutions for the set of synucleinopathies.
The organizing committee of ISAS 2018 would like to acknowledge the following companies for their support:
Additional acknowledgements to the following institutions for their financial support in the research of synucleinopathies:
-LIMITED PLACES (80 ATTENDEES)
-DEADLINE FOR REGISTRATION: APRIL 12TH, 2018
-REGISTRATION IS MANDATORY in order to be able to attend the symposium
-For any QUESTIONS about symposium & registration, CONTACT US with an email to [email protected]
-REGISTER ONLINE in the following link:
SALÓN DE ACTOS. CRUCES UNIVERSITY HOSPITAL. PLAZA DE CRUCES 12, BARAKALDO (SPAIN)
The Cruces University Hospital is located in the neighborhood of the same name in the municipality of Barakaldo, 10 kilometers from Bilbao. Its access by road can be easily done by car, since it is located next to the A-8 motorway. Under the square in front of the Hospital there is a paid parking and the neighborhood also has several parking areas that allow half-day stays. There are also stops for public buses coming from all the towns of its surroundings and there is a taxi service inside the hospital enclosure.
The most practical way to get to the Hospital from Bilbao is by metro (“Gurutzeta/Cruces” stop)