APRIL 13TH, BILBAO

II International Symposium on Alpha-Synuclein

(ISAS 2018)

INTRODUCTION

Alpha-synuclein is a ubiquitous protein in the healthy brain that is found in the presynaptic terminals of neurons. Although its function is not well known, it is believed that it favors the formation of synaptic vesicles that contain neurotransmitters. In particular, it seems that alpha-synuclein has a special role in the regulation of the release of dopamine. Due to different pathological mechanisms, alpha-synuclein can be added forming insoluble intra and extraneuronal fibrillar structures that give rise to the Lewy bodies, characteristic of the set of diseases called synucleinopathies. The most well-known representative of synucleinopathies is Parkinson's disease, which is neither more nor less the second most frequent neurodegenerative disease in the world after Alzheimer's disease. However, the spectrum of synucleinopathies is broader than Parkinson's disease, and it also includes other less frequent diseases such as Lewy body dementia, multiple systemic atrophy, REM sleep behavior disorder and pure autonomic failure. This set of diseases, the synucleinopathies, share many neurobiological and phenotypic similarities, which favors that they often overlap each other.

PURPOSE

This symposium, which is the second edition of the meeting with the same name organized by our group at the Biocruces HRI and the Cruces University Hospital in 2016, was born as a result of a double initiative with which, on the one hand, we intend to promote dissemination and training in advances and regional and international research projects related to the pathophysiology, diagnosis and treatment of synucleinopathies, and on the other hand we want to encourage interaction and collaboration among the groups dedicated to the study of synucleinopathies, and also to stimulate students and the personnel in training in the field of biomedicine to become involved in research on synucleinopathies.

TO WHOM

- Health staff (doctors, nurses, psychologists, etc.) interested in neurosciences, especially in the field of neurology, neuropsychology, neurophysiology, neuroradiology, neurorehabilitation and neurosurgery.

- Pre-doc and post-doc researchers and undergraduate or master students in the field of biomedicine with an interest in neurosciences (Biology, Biochemistry, Biomedical Engineering, Biophysics, etc.).

SPEAKERS

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JC Gómez Esteban Neurodegenerative Diseases Group, Biocruces HRI (Barakaldo, Spain)

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Beatriz Tijero Neurodegenerative Diseases Group, Biocruces HRI (Barakaldo, Spain)

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Javier Ruiz Martínez Movement Disorders Unit Donostia U. Hospital - Biodonostia HRI (San Sebastian, Spain)

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Vikram Khurana Ann Romney Center for Neurologic Diseases, Harvard Medical School, Harvard Stem Cell Institute (Boston, USA)

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Joaquín Castilla Prion lab - CIC bioGUNE. Proteomics unit., Scientific-Technological Park of Bizkaia (Zamudio, Spain)

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Fabio Cavaliere Laboratory of Neurobiology, Achucarro Basque Center for Neuroscience (Leioa, Spain)

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Nicolás Cuenca Physiology, Genetics & Microbiology Dep., Alicante University (Alicante, Spain)

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Rosario S. Pernaute Andalusian Initiative for Advanced Therapies (Sevilla, Spain)

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Mazahir Hasan Laboratory of Memory Circuits - Achucarro Basque Center of Neuroscience (Leioa, Spain)

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Iñigo Gabilondo Neurodegenerative Diseases Group, Biocruces HRI (Barakaldo, Spain)

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Manuel Fernández Dementia Unit Cruces U. Hospital - Biocruces HRI (Barakaldo, Spain)

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Maria-Rosario Luquin Centro de Investigación Médica Aplicada (CIMA), University of Navarra (Pamplona, Spain)

PROGRAMME

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